Dietary supplements and Nutraceuticals Notes, PDF, Books
Occurrence and Characteristic Features:
- Naringin is a flavanone glycoside, a type of flavonoid found primarily in citrus fruits, especially:
- Grapefruit (particularly the white pith)
- Oranges (higher concentration in peels than flesh)
- Lemons (smaller amounts compared to grapefruit and oranges)
- Chemically, Naringin consists of a disaccharide sugar unit (neohesperidose) linked to a flavanone aglycone called naringenin. This linkage contributes to its characteristic bitterness.
Medicinal Benefits:
Naringin exhibits a range of potential health benefits, although some require further research for definitive conclusions:
- Antioxidant Activity: Like other flavonoids, Naringin scavenges free radicals, protecting cells from oxidative damage linked to chronic diseases.
- Anti-inflammatory Properties: Naringin might possess anti-inflammatory effects, potentially aiding in conditions like arthritis and inflammatory bowel disease.
- Blood Sugar Control: Some studies suggest Naringin may improve blood sugar control, potentially beneficial for managing type 2 diabetes. However, more research is needed.
- Cardiovascular Health: Naringin’s antioxidant and anti-inflammatory properties might contribute to improved heart health by lowering bad cholesterol (LDL) and reducing blood pressure. However, evidence is not yet conclusive.
- Weight Management: Naringin may play a role in weight management by increasing feelings of fullness and potentially boosting metabolism. More research is needed to confirm these effects.
- Anti-Cancer Properties: Early research suggests Naringin may have anti-cancer properties, but the evidence is limited and requires further investigation.
Important Points to Consider:
- Naringin is responsible for the bitter taste of grapefruit juice. Commercial processing often uses enzymes to break down Naringin, reducing bitterness.
- Naringin can interact with certain medications, particularly those metabolized by the CYP3A4 enzyme. It’s crucial to consult a healthcare professional before taking supplements containing Naringin.
- The bioavailability of Naringin can be limited due to its breakdown in the gut. Research is ongoing to explore methods for enhancing its absorption.
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