May 30, 2024

Preparation and standardization of Sulphuric acid standard solution

Preparation and standardization of Sulphuric acid standard solution


Pharmaceutical Analysis I Practical: Limit test for (1) Chloride (2) Sulphate (3) Iron (4) Arsenic Preparation and standardisation of (1) Sodium hydroxide (2) Sulphuric acid (3) Sodium thiosulfate (4) Potassium permanganate (5) Ceric ammonium sulphate Assay (1) Ammonium chloride (2) Ferrous sulphate(3) Copper sulphate (4) Calcium gluconate (5) Hydrogen peroxide (6) Sodium benzoate (7) Sodium Chloride Determination of Normality (1) Conductometric titration of strong acid against a strong base (2) Conductometric titration of strong acid and weak acid against a strong base (3) Potentiometric titration


Aim

To Prepare and standardize 0.5 M Sulphuric acid standard solution

Principle

This is direct acid-base titration in which sulphuric acid reacts with sodium carbonate to form carbon dioxide and water. As carbonic acid formed in reaction can change the color of indicator before equivalence point it is advisable to boil solution to perform the errorless titration

Procedure

Preparation of 0.5M Sulphuric acid standard solution

Add slowly, with stirring,   ml of sulphuric acid  to  about 1000 ml  of    water, allow to cool 25°C

Standardization of 0.5M Sulphuric acid solution Weigh accurately about 1.5 g of anhydrous sodium carbonate, previously heated at about 270ºC for 1 hour. Dissolve it in 100 ml of water and add 0.1 ml of methyl red solution. Add the acid slowly from a burette, with constant stirring, until the solution becomes faintly pink. Heat the solution to boiling, cool, and continue the titration. Heat again to boiling and titrate further as necessary until the faint pink color is no longer affected by continued boiling

Reference

Indian Pharmacopoeia, 2007, volume1, pg. No.316


First Year B Pharm Notes, Syllabus, Books, PDF Subjectwise/Topicwise

F Y B Pharm Sem-IF Y B Pharm Sem-II
BP101T Human Anatomy and Physiology I TheoryBP201T Human Anatomy and Physiology II – Theory
BP102T Pharmaceutical Analysis I TheoryBP202T Pharmaceutical Organic Chemistry I Theory
BP103T Pharmaceutics I TheoryBP203T Biochemistry – Theory
BP104T Pharmaceutical Inorganic Chemistry TheoryBP204T Pathophysiology – Theory
BP105T Communication skills TheoryBP205T Computer Applications in Pharmacy Theory
BP106RBT Remedial BiologyBP206T Environmental sciences – Theory
BP106RMT Remedial Mathematics TheoryBP207P Human Anatomy and Physiology II Practical
BP107P Human Anatomy and Physiology PracticalBP208P Pharmaceutical Organic Chemistry I Practical
BP108P Pharmaceutical Analysis I PracticalBP209P Biochemistry Practical
BP109P Pharmaceutics I PracticalBP210P Computer Applications in Pharmacy Practical
BP110P Pharmaceutical Inorganic Chemistry Practical
BP111P Communication skills Practical
BP112RBP Remedial Biology Practical


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