Preparation and standardization of Sulphuric acid standard solution

Preparation and standardization of Sulphuric acid standard solution

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Pharmaceutical Analysis I Practical: Limit test for (1) Chloride (2) Sulphate (3) Iron (4) Arsenic Preparation and standardisation of (1) Sodium hydroxide (2) Sulphuric acid (3) Sodium thiosulfate (4) Potassium permanganate (5) Ceric ammonium sulphate Assay (1) Ammonium chloride (2) Ferrous sulphate(3) Copper sulphate (4) Calcium gluconate (5) Hydrogen peroxide (6) Sodium benzoate (7) Sodium Chloride Determination of Normality (1) Conductometric titration of strong acid against a strong base (2) Conductometric titration of strong acid and weak acid against a strong base (3) Potentiometric titration

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Aim

To Prepare and standardize 0.5 M Sulphuric acid standard solution

Principle

This is direct acid-base titration in which sulphuric acid reacts with sodium carbonate to form carbon dioxide and water. As carbonic acid formed in reaction can change the color of indicator before equivalence point it is advisable to boil solution to perform the errorless titration

Procedure

Preparation of 0.5M Sulphuric acid standard solution

Add slowly, with stirring,   ml of sulphuric acid  to  about 1000 ml  of    water, allow to cool 25°C

Standardization of 0.5M Sulphuric acid solution Weigh accurately about 1.5 g of anhydrous sodium carbonate, previously heated at about 270ºC for 1 hour. Dissolve it in 100 ml of water and add 0.1 ml of methyl red solution. Add the acid slowly from a burette, with constant stirring, until the solution becomes faintly pink. Heat the solution to boiling, cool, and continue the titration. Heat again to boiling and titrate further as necessary until the faint pink color is no longer affected by continued boiling

Reference

Indian Pharmacopoeia, 2007, volume1, pg. No.316

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First Year B Pharm Notes, Syllabus, Books, PDF Subjectwise/Topicwise

F Y B Pharm Sem-I	F Y B Pharm Sem-II
BP101T Human Anatomy and Physiology I Theory	BP201T Human Anatomy and Physiology II – Theory
BP102T Pharmaceutical Analysis I Theory	BP202T Pharmaceutical Organic Chemistry I Theory
BP103T Pharmaceutics I Theory	BP203T Biochemistry – Theory
BP104T Pharmaceutical Inorganic Chemistry Theory	BP204T Pathophysiology – Theory
BP105T Communication skills Theory	BP205T Computer Applications in Pharmacy Theory
BP106RBT Remedial Biology	BP206T Environmental sciences – Theory
BP106RMT Remedial Mathematics Theory	BP207P Human Anatomy and Physiology II Practical
BP107P Human Anatomy and Physiology Practical	BP208P Pharmaceutical Organic Chemistry I Practical
BP108P Pharmaceutical Analysis I Practical	BP209P Biochemistry Practical
BP109P Pharmaceutics I Practical	BP210P Computer Applications in Pharmacy Practical
BP110P Pharmaceutical Inorganic Chemistry Practical
BP111P Communication skills Practical
BP112RBP Remedial Biology Practical

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• BP102T Pharmaceutical Analysis I – Theory
• BP108P Pharmaceutical Analysis I Practical
• Preparation and standardization of Sodium hydroxide Standard solution
• Limit Test of Chloride Pharmaceutical Analysis I Practical, Lab Manual
• Limit Test of Sulphate Pharmaceutical Analysis I Practical, Lab Manual

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• Blue waffle disease
• b pharmacy syllabus

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