February 23, 2024

Solvents in Non aqueous titration

Solvents in Non aqueous titration

Non-aqueous titration is a type of acid-base titration that involves the use of a non-aqueous solvent as the titration medium instead of water. The choice of solvent depends on the properties of the analyte, the titrant, and the indicator, as well as the desired accuracy and precision of the analysis.

Some common non-aqueous solvents used in acid-base titrations include:

Methanol:

Methanol is a common non-aqueous solvent used in acid-base titrations, especially for the determination of weakly acidic or basic compounds. It is a polar solvent that dissolves many organic and inorganic compounds, and has a relatively low boiling point, which makes it easy to evaporate and remove from the sample after the titration is complete.

Acetic acid:

Acetic acid is another common non-aqueous solvent used in acid-base titrations, particularly for the determination of weak bases. It is a weak acid that can be used as a solvent and as an acid component of the titrant. It is also volatile, making it easy to remove after the titration is complete.

Dimethylformamide (DMF):

DMF is a polar aprotic solvent that is used in some acid-base titrations. It has a high boiling point and dissolves many organic and inorganic compounds, making it useful for the titration of substances that are insoluble in water.

Tetrahydrofuran (THF):

THF is a non-polar solvent that is used in some acid-base titrations. It has a low boiling point and dissolves many organic and inorganic compounds, making it useful for the titration of substances that are soluble in non-polar solvents.

Dioxane:

Dioxane is a polar aprotic solvent that is used in some acid-base titrations. It has a high boiling point and dissolves many organic and inorganic compounds, making it useful for the titration of substances that are insoluble in water.

The choice of solvent for a non-aqueous titration depends on several factors, including the solubility of the analyte and titrant in the solvent, the pKa of the acid and base used, and the desired accuracy and precision of the analysis. The use of a non-aqueous solvent can provide advantages over aqueous titrations, such as improved solubility and better precision, but it also requires careful attention to the selection and handling of the solvent.

First Year B Pharm Notes, Syllabus, Books, PDF Subjectwise/Topicwise

F Y B Pharm Sem-IF Y B Pharm Sem-II
BP101T Human Anatomy and Physiology I TheoryBP201T Human Anatomy and Physiology II – Theory
BP102T Pharmaceutical Analysis I TheoryBP202T Pharmaceutical Organic Chemistry I Theory
BP103T Pharmaceutics I TheoryBP203T Biochemistry – Theory
BP104T Pharmaceutical Inorganic Chemistry TheoryBP204T Pathophysiology – Theory
BP105T Communication skills TheoryBP205T Computer Applications in Pharmacy Theory
BP106RBT Remedial BiologyBP206T Environmental sciences – Theory
BP106RMT Remedial Mathematics TheoryBP207P Human Anatomy and Physiology II Practical
BP107P Human Anatomy and Physiology PracticalBP208P Pharmaceutical Organic Chemistry I Practical
BP108P Pharmaceutical Analysis I PracticalBP209P Biochemistry Practical
BP109P Pharmaceutics I PracticalBP210P Computer Applications in Pharmacy Practical
BP110P Pharmaceutical Inorganic Chemistry Practical
BP111P Communication skills Practical
BP112RBP Remedial Biology Practical

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