July 19, 2024

Solubility enhancement techniques: Liquid dosage forms

Solubility enhancement techniques: Liquid dosage forms

Solubility is an essential factor that affects the effectiveness of a medication. When a medication has low solubility, it can be challenging to achieve the desired therapeutic effect. Therefore, several techniques are used to enhance the solubility of drugs in liquid dosage forms. Some of the common solubility enhancement techniques used in liquid dosage forms include:

  1. Co-solvents: Co-solvents are solvents that are added to a drug to enhance its solubility. They work by increasing the polarity of the solvent, which increases the solubility of the drug. Common co-solvents include propylene glycol, ethanol, and polyethylene glycol.
  2. Micronization: Micronization involves reducing the size of drug particles to increase the surface area available for dissolution. This technique is commonly used for poorly soluble drugs.
  3. Cyclodextrins: Cyclodextrins are cyclic oligosaccharides that can form inclusion complexes with drugs. This technique is used to increase the solubility of drugs by encapsulating them in the cyclodextrin cavity.
  4. Surfactants: Surfactants are compounds that reduce the surface tension of a liquid, allowing it to mix more easily with other substances. They can be used to enhance the solubility of drugs in liquid dosage forms.
  5. Complexation: Complexation involves the formation of a complex between the drug and a complexing agent. The complexing agent can be used to increase the solubility of drugs in liquid dosage forms.
  6. Solid Dispersion: In solid dispersion technique, the drug is dispersed into a water-soluble carrier, increasing the surface area of the drug, and hence its solubility.

These solubility enhancement techniques help improve the bioavailability of the drug and ensure that it reaches its target site effectively. The choice of technique used depends on the physicochemical properties of the drug and the desired properties of the final liquid dosage form.

First Year B Pharm Notes, Syllabus, Books, PDF Subjectwise/Topicwise

F Y B Pharm Sem-IS Y B Pharm Sem-II
BP101T Human Anatomy and Physiology I TheoryBP201T Human Anatomy and Physiology II – Theory
BP102T Pharmaceutical Analysis I TheoryBP202T Pharmaceutical Organic Chemistry I Theory
BP103T Pharmaceutics I TheoryBP203T Biochemistry – Theory
BP104T Pharmaceutical Inorganic Chemistry TheoryBP204T Pathophysiology – Theory
BP105T Communication skills TheoryBP205T Computer Applications in Pharmacy Theory
BP106RBT Remedial BiologyBP206T Environmental sciences – Theory
BP106RMT Remedial Mathematics TheoryBP207P Human Anatomy and Physiology II Practical
BP107P Human Anatomy and Physiology PracticalBP208P Pharmaceutical Organic Chemistry I Practical
BP108P Pharmaceutical Analysis I PracticalBP209P Biochemistry Practical
BP109P Pharmaceutics I PracticalBP210P Computer Applications in Pharmacy Practical
BP110P Pharmaceutical Inorganic Chemistry Practical
BP111P Communication skills Practical
BP112RBP Remedial Biology Practical

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