February 23, 2024

Principle and steps involved in the gravimetric analysis

Principle and steps involved in the gravimetric analysis

Gravimetric analysis is a quantitative analytical method that involves the determination of the mass of a substance by its chemical conversion to a compound of known composition. The principle involved in gravimetric analysis is based on the law of conservation of mass, which states that mass is neither created nor destroyed during a chemical reaction.

Gravimetric analysis involves the following steps:

  1. Sample preparation: The sample is first collected and prepared for analysis. The sample should be representative of the entire sample population and should be homogenous.
  2. Precipitation: The analyte is converted into a solid precipitate by adding a reagent that forms a sparingly soluble compound with the analyte. The precipitate should be pure and of known composition.
  3. Filtration: The precipitate is separated from the solution by filtration. The filter paper used should be of known weight and should not react with the precipitate.
  4. Washing: The precipitate is washed with a suitable solvent to remove any impurities that may have adsorbed on its surface.
  5. Drying: The precipitate is dried in an oven to remove any remaining water molecules.
  6. Weighing: The dried precipitate is weighed on a balance to determine its mass.
  7. Calculation: The mass of the analyte is calculated from the mass of the precipitate and the stoichiometry of the reaction.

Gravimetric analysis is a precise and accurate method for determining the amount of an analyte in a sample. However, it requires careful sample preparation and handling to minimize errors. The method is widely used in various fields, including pharmaceuticals, environmental monitoring, and materials science.

First Year B Pharm Notes, Syllabus, Books, PDF Subjectwise/Topicwise

F Y B Pharm Sem-IF Y B Pharm Sem-II
BP101T Human Anatomy and Physiology I TheoryBP201T Human Anatomy and Physiology II – Theory
BP102T Pharmaceutical Analysis I TheoryBP202T Pharmaceutical Organic Chemistry I Theory
BP103T Pharmaceutics I TheoryBP203T Biochemistry – Theory
BP104T Pharmaceutical Inorganic Chemistry TheoryBP204T Pathophysiology – Theory
BP105T Communication skills TheoryBP205T Computer Applications in Pharmacy Theory
BP106RBT Remedial BiologyBP206T Environmental sciences – Theory
BP106RMT Remedial Mathematics TheoryBP207P Human Anatomy and Physiology II Practical
BP107P Human Anatomy and Physiology PracticalBP208P Pharmaceutical Organic Chemistry I Practical
BP108P Pharmaceutical Analysis I PracticalBP209P Biochemistry Practical
BP109P Pharmaceutics I PracticalBP210P Computer Applications in Pharmacy Practical
BP110P Pharmaceutical Inorganic Chemistry Practical
BP111P Communication skills Practical
BP112RBP Remedial Biology Practical

Suggested readings: