Primary and secondary standards in pharmaceutical analysis
Primary and secondary standards are two types of reference materials that are commonly used in pharmaceutical analysis.
Primary standards are highly purified substances that are stable, non-hygroscopic, and easily weighed. They are used to prepare solutions of accurately known concentration for use in analytical methods. Primary standards are characterized by their high purity, low water content, and high stability. Common primary standards used in pharmaceutical analysis include potassium hydrogen phthalate (KHP) and sodium oxalate.
Secondary standards, on the other hand, are reference materials that have a known concentration but are not necessarily of high purity. They are typically used to calibrate analytical instruments or to check the accuracy and precision of analytical methods. Secondary standards are often less expensive and more readily available than primary standards. Common examples of secondary standards used in pharmaceutical analysis include sodium chloride, sucrose, and glucose.
It is important to use appropriate reference materials in pharmaceutical analysis to ensure the accuracy and reliability of the analytical results. The choice of the appropriate standard will depend on the specific needs of the analysis and the properties of the sample being analyzed. The accuracy and precision of the analytical methods can be affected by the quality of the standard used, and therefore, it is essential to use high-quality reference materials for accurate and reliable results.
First Year B Pharm Notes, Syllabus, Books, PDF Subjectwise/Topicwise