Physical Pharmacy II MU BPH_C_402_T

Physical Pharmacy II

No. Details Hours
1 Chemical kinetics and drug stability 11
1.1 Molecularity, order of a reaction, specific rate constant 2


1.2 Reaction kinetics: 4
zero, pseudo-zero, first & second order (problems), units of basic rate constants, determination of reaction
order, Energy of activation
1.3 Physical  and  chemical  factors  influencing  the  chemical  degradation  of  pharmaceutical  product: 3
temperature, solvent, ionic strength, dielectric constant, specific & general acid base catalysis.
1.4 Accelerated stability testing in expiration dating of pharmaceutical dosage forms. 2
2 Dissolution and diffusion 9
2.1 Diffusion: Concept, and applications, diffusion through biological membranes, drug release 2
2.2 Fick’s Laws of diffusion, Steady state diffusion, driving forces for diffusion in pharmaceutical systems,
permeability 3
2.3 Measurement of diffusion 1
2.4 Concept of dissolution, dissolution mechanism 1
2.5 Noyes Whitney equation, factors affecting dissolution 1
2.6 Intrinsic Dissolution Rate, Hixson – Crowell Law, measurement of dissolution rates 1
3 Complexation and protein binding 6
3.1 Introduction, classification of complexes 2
3.2 Pharmaceutical applications of complexes 1
3.3 Method of analysis of complexes 1
3.4 Protein binding, complexation and drug action, stability constants 2
4 Coarse dispersions 8
4.1 Classification of dispersions, properties of coarse, colloidal and molecular dispersions 1
4.2 Thermodynamic and kinetic stability of dispersed systems 1
4.3 Electric Properties of Interfaces: Nernst and zeta potential, effect of electrolytes 1
4.4 Suspensions: DLVO theory, flocculated and deflocculated systems, controlled flocculation, physical 3
stability of suspensions
4.5 Emulsions: Theories of emulsification, physical stability of emulsions 2
6 Colloids 7
6.1 Classification and preparation 2
6.2 Colloid properties: optical, kinetic and electrical 2
6.3 Stability of colloids and Schultz Hardy rule, Protective colloid and gold number 2
6.4 Pharmaceutical applications of colloids 1
7 Biopharmaceutics 7
7.1 Introduction to biopharmaceutics and Pharmacokinetics, concept of ADME, bioavailability 2
7.2 Mechanisms of drug absorption 1
7.3 Factors affecting drug absorption: Physicochemical, physiological and dosage form factors 3
7.4 Introduction to Biopharmaceutical Classification System of drugs 1


Refer to latest edition

  1. J. Sinko, ‘Martin’s Physical Pharmacy and Pharmaceutical Sciences’ Fifth edition, Lippincott Williams and Wilkins, Indian Edition distributed by B.I. Publications Pvt. Ltd, 2006.
  1. Pharmaceutical Dosage Forms And Drug Delivery Systems, Howard C. Ansel, Nicholas G. Popovich, Loyd V.
  2. Pharmaceutics: The Science Of Dosage Form Design, Michael E.Aulton
  3. Bahl and Tuli, ‘Essentials of Physical Chemistry’ S. Chand and Company Ltd. Ramnagar, New Delhi-110055.
  4. Essentials of Physical Pharmacy , C.V.S Subrahmanyum, Vallabh Prakashan.
  5. Textbook of Physical Pharmaceutics, C.V.S Subrahmanyum, Vallabh Prakashan
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