Pharmacology MCQ

Pharmacokinetics is:
a) The study of biological and therapeutic effects of drugs
b) The study of absorption, distribution, metabolism and excretion of drugs
c) The study of mechanisms of drug action
d) The study of methods of new drug development

What does “pharmacokinetics” include?
a) Complications of drug therapy
b) Drug biotransformation in the organism
c) Influence of drugs on metabolism processes
d) Influence of drugs on genes

What does “pharmacokinetics” include?
a) Pharmacological effects of drugs
b) Unwanted effects of drugs
c) Chemical structure of a medicinal agent
d) Distribution of drugs in the organism

What does “pharmacokinetics” include?
a) Localization of drug action
b) Mechanisms of drug action
c) Excretion of substances
d) Interaction of substances

The main mechanism of most drugs absorption in GI tract is:
a) Active transport (carrier-mediated diffusion)
b) Filtration (aqueous diffusion)
c) Endocytosis and exocytosis
d) Passive diffusion (lipid diffusion)

What kind of substances can’t permeate membranes by passive diffusion?
a) Lipid-soluble
b) Non-ionized substances
c) Hydrophobic substances
d) Hydrophilic substances

A hydrophilic medicinal agent has the following property:
a) Low ability to penetrate through the cell membrane lipids
b) Penetrate through membranes by means of endocytosis
c) Easy permeation through the blood-brain barrier
d) High reabsorption in renal tubules

What is implied by «active transport»?
a) Transport of drugs trough a membrane by means of diffusion
b) Transport without energy consumption
c) Engulf of drug by a cell membrane with a new vesicle formation
d) Transport against concentration gradient

What does the term “bioavailability” mean?
a) Plasma protein binding degree of substance
b) Permeability through the brain-blood barrier
c) Fraction of an uncharged drug reaching the systemic circulation following any route administration
d) Amount of a substance in urine relative to the initial doze

The reasons determing bioavailability are:
a) Rheological parameters of blood
b) Amount of a substance obtained orally and quantity of intakes
c) Extent of absorption and hepatic first-pass effect
d) Glomerular filtration rate

Pick out the appropriate alimentary route of administration when passage of drugs through liver is minimized:
a) Oral
b) Transdermal
c) Rectal
d) Intraduodenal

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