Mixing Pharmaceutical engineering MCQ with answers
Pharm Engg Chapterwise MCQ: UNIT-I MCQ * Flow of fluids * Size reduction * Size separation UNIT-II MCQ *Heat transfer *Distillation *Evaporation UNIT-III MCQ *Drying * Mixing UNIT-IV MCQ * Filtration * Centrifugation * UNIT-V MCQ Materials of construction * Corrosion
a. Dissimilar charges
b. Dissimilar forces
c. Dissimilar ions
d. Dissimilar particles
Answer: Dissimilar particles
a. Dilatant flow
b. Plastic flow
c. Pseudoplastic flow
d. Thixotropy
Answer: Dilatant flow
a. Shell and blade are stationary
b. Shell and blade rotate
c. Shell is stationary and blade rotates
d. Shell rotates and blade is stationary
Answer: Shell is stationary and blade rotates
a. Barrel mixer
b. Double cone blender
c. Ribbon mixer
d. Zigzag mixer
Answer: Ribbon mixer
a. axial and tangential
b. axial or tangential
c. radial and tangential
d. radial or tangential
Answer: radial and tangential
a. Electrostatic force
b. Gravitational force
c. Surface force
d. Van der Walls force
Answer: Gravitational force
a. First order
b. Pseudo-first order
c. Second-order
d. Zero order
Answer: First order
a. Attraction
b. Collisions
c. Diffusion
d. Repulsion
Answer: Repulsion
a. Electrostatic forces
b. London forces
c. Surface forces
d. Van der Waals forces
Answer: Surface forces
a. Sizing
b. Spatulation
c. Trituration
d. Tumbling
Answer: Sizing
Mixing in Pharmaceutical Engineering: A Crucial Step for Uniformity
Citation: Chaudhari, M. (2022). Mixing in Pharmaceutical Engineering: A Crucial Step for Uniformity. Pharmacy Infoline. https://doi.org/10.5281/zenodo.10814572
Mixing is a fundamental process in pharmaceutical engineering, ensuring the uniform distribution of ingredients within a medication. This homogeneity is critical for several reasons:
- Dosage Accuracy: Uniform mixing guarantees that each dose of a medication contains the correct amount of active pharmaceutical ingredient (API) and inactive excipients. Inconsistent mixing can lead to some doses having too little or too much medication, impacting efficacy and safety.
- Product Quality: Mixing influences properties like flowability, stability, and dissolution rate of the final product. Uneven mixing can lead to problems with processing the medication further or cause inconsistencies in how quickly the drug enters the bloodstream.
Types of Mixing:
- Dry Mixing: This involves blending dry powders, often used for tablets, capsules, and some topical preparations.
- Wet Mixing: Liquids are incorporated with powders to create pastes, suspensions, or granulation for tablets.
Mixing Equipment:
- V-blenders: These utilize a V-shaped container that tumbles the materials, promoting a gentle, homogenous mix.
- Ribbon blenders: A horizontal ribbon agitator moves the materials within a U-shaped trough, achieving good uniformity.
- High-shear mixers: These employ intense impellers to disperse and break down aggregates, particularly useful for viscous mixtures.
Factors Affecting Mixing:
- Material properties: Particle size, density, and flow characteristics of the ingredients can influence mixing efficiency.
- Mixing time: Sufficient time is needed for even distribution, but over-mixing can lead to segregation or degradation of some materials.
- Blender selection: Choosing the right equipment for the type and volume of materials is crucial.
Ensuring Mixing Efficiency:
- Mixing uniformity tests: Statistical sampling and analysis ensure the final blend meets pre-defined criteria for uniformity.
- Process validation: Establishing and documenting optimal mixing parameters for each product is essential.
By understanding the importance and complexities of mixing in pharmaceutical engineering, manufacturers can ensure consistent, high-quality medications for patient safety and efficacy.
