May 30, 2024

Historical design: Response Surface methodology

Historical design: Response Surface methodology

Response Surface Methodology (RSM) is a statistical experimental design technique used to study the relationship between a response variable and several predictor variables. In RSM, historical design is a type of design that is used when there is prior knowledge or historical data available about the factors and their levels.

Historical design involves using the existing knowledge about the factors and their levels to create a design matrix that can be used to conduct the experiment. The design matrix is based on a statistical model that relates the response variable to the predictor variables, and it is created using software tools such as Design Expert or JMP.

The steps involved in historical design in RSM are as follows:

  1. Identify the response variable and predictor variables: The first step in historical design is to identify the response variable and predictor variables. The response variable is the variable that is being studied, while the predictor variables are the variables that are expected to have an effect on the response variable.
  2. Identify the levels of the predictor variables: The next step is to identify the levels of the predictor variables based on prior knowledge or historical data. The levels should be chosen so that they cover the expected range of the predictor variables.
  3. Determine the number of runs: Once the levels of the predictor variables have been identified, the next step is to determine the number of runs required for the experiment. The number of runs is determined by the statistical model and the degree of precision required.
  4. Create the design matrix: Using the identified levels and the number of runs, a design matrix is created using software tools such as Design Expert or JMP. The design matrix specifies the combinations of the levels of the predictor variables that are to be used in the experiment.
  5. Conduct the experiment: The experiment is conducted according to the design matrix, and the response variable is measured for each combination of predictor variable levels.
  6. Analyze the data: Once the experiment is complete, the data is analyzed using statistical methods such as regression analysis. The statistical model is used to estimate the effects of the predictor variables on the response variable and to optimize the response variable based on the desired criteria.

In conclusion, historical design is a type of design in RSM that is used when there is prior knowledge or historical data available about the factors and their levels. The design matrix is created based on a statistical model that relates the response variable to the predictor variables, and the experiment is conducted according to the design matrix. The data is then analyzed using statistical methods to estimate the effects of the predictor variables on the response variable and to optimize the response variable based on the desired criteria.

Final Year B Pharm Notes, Syllabus, Books, PDF Subjectwise/Topicwise

Final Year B Pharm Sem VIIBP701T Instrumental Methods of Analysis Theory
BP702T Industrial Pharmacy TheoryBP703T Pharmacy Practice Theory
BP704T Novel Drug Delivery System TheoryBP705 P Instrumental Methods of Analysis Practical
Final Year B Pharm Sem VIIBP801T Biostatistics and Research Methodology Theory
BP802T Social and Preventive Pharmacy TheoryBP803ET Pharmaceutical Marketing Theory
BP804ET Pharmaceutical Regulatory Science TheoryBP805ET Pharmacovigilance Theory
BP806ET Quality Control and Standardization of Herbals TheoryBP807ET Computer-Aided Drug Design Theory
BP808ET Cell and Molecular Biology TheoryBP809ET Cosmetic Science Theory
BP810ET Experimental Pharmacology TheoryBP811ET Advanced Instrumentation Techniques Theory
BP812ET Dietary supplements and NutraceuticalsPharmaceutical Product Development

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