Hexamine synthesis from Formaldehyde: Mechanism, Structure, Use
BP607P Medicinal Chemistry III Practical: I Preparation of drugs Sulphanilamide * 7-Hydroxy, 4-methyl coumarin * Chlorobutanol * Triphenyl imidazole * Tolbutamide * Hexamine II Assay of drugs Isonicotinic acid hydrazide * Chloroquine * Metronidazole * Dapsone * Chlorpheniramine maleate * Benzyl penicillin III Microwave irradiation technique Synthesis of Phenytoin by Microwave * Synthesis of Aspirin by Microwave IV Drawing structures and reactions using chem draw®
Aim
To prepare and submit hexamine from formaldehyde and calculate it’s Percentage Yield.
Principle
Hexamine is a heterocyclic organic compound (CH2)6N4. It has a symmetrical tetrahedral cage-like structure. It is prepared by a condensation reaction between formaldehyde and ammonia.
Reaction
Chemical Required
Formaldehyde – 4.7 g
Ammonia Solution – 7 g
Procedure
About 4.7g of 30% formaldehyde solution was taken in a beaker and add 7g of 24% ammonia solution, until the solution is slightly alkaline.
The mixture was heated on a water bath for 5 minutes and allowed to stand for 15 minutes.
The solution was filtered and then evaporated on a direct flame using china dish to a thick paste.
The hexamine crystals are obtained and dried. It was recrystallized from water or alcohol.
Hexamine forms colourless, odourless crystals, which are soluble in water and 90% alcohol.
Use
Urinary anti-infective agent
Report
Hexamine was prepared and submitted. Report the following
Theoretical Yield:
Practical Yield:
Percentage Yield:
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