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Hexamine synthesis from Formaldehyde: Mechanism, Structure, Use


BP607P Medicinal Chemistry III Practical: I Preparation of drugs Sulphanilamide * 7-Hydroxy, 4-methyl coumarin * Chlorobutanol * Triphenyl imidazole * Tolbutamide * Hexamine II Assay of drugs Isonicotinic acid hydrazide * Chloroquine * Metronidazole * Dapsone * Chlorpheniramine maleate * Benzyl penicillin III Microwave irradiation technique Synthesis of Phenytoin by Microwave * Synthesis of Aspirin by Microwave IV Drawing structures and reactions using chem draw®


Aim

To prepare and submit hexamine from formaldehyde and calculate it’s Percentage Yield.

Principle

Hexamine is a heterocyclic organic compound (CH2)6N4. It has a symmetrical tetrahedral cage-like structure. It is prepared by a condensation reaction between formaldehyde and ammonia.

Reaction

Synthesis of Hexamine

Chemical Required

Formaldehyde – 4.7 g
Ammonia Solution – 7 g

Procedure

About 4.7g of 30% formaldehyde solution was taken in a beaker and add 7g of 24% ammonia solution, until the solution is slightly alkaline.
The mixture was heated on a water bath for 5 minutes and allowed to stand for 15 minutes.
The solution was filtered and then evaporated on a direct flame using china dish to a thick paste.
The hexamine crystals are obtained and dried. It was recrystallized from water or alcohol.
Hexamine forms colourless, odourless crystals, which are soluble in water and 90% alcohol.

Use

Urinary anti-infective agent

Report

Hexamine was prepared and submitted. Report the following
Theoretical Yield:
Practical Yield:
Percentage Yield:


Third Year B Pharm Notes, Syllabus, Books, PDF Subjectwise/Topicwise

T Y B Pharm Sem VT Y B Pharm Sem VI
BP501T Medicinal Chemistry II TheoryBP601T Medicinal Chemistry III Theory
BP502T Industrial Pharmacy TheoryBP602T Pharmacology III Theory
BP503T Pharmacology II TheoryBP603T Herbal Drug Technology Theory
BP504T Pharmacognosy II TheoryBP604T Biopharmaceutics and Pharmacokinetics Theory
BP505T Pharmaceutical Jurisprudence TheoryBP605T Pharmaceutical Biotechnology – Theory
BP506P Industrial Pharmacy I PracticalBP606T Quality Assurance Theory
BP507P Pharmacology II PracticalBP607P Medicinal chemistry III Practical
BP508P Pharmacognosy II PracticalBP608P Pharmacology III Practical
BP609P Herbal Drug Technology Practical

Suggested readings

  • BP607P Medicinal Chemistry III Practical
  • Chlorobutanol Synthesis
  • Benzoic acid from benzamide synthesis: Pharmaceutical Chemistry Practical
  • 7-Hydroxy 4-methyl coumarin synthesis
  • Tolbutamide synthesis

B Pharmacy Notes (Subjectwise/Topicwise)

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  • 1st Year D Pharmacy
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