Coating of tablets: film coating of tablets/granules

Coating of tablets- film coating of tablets/granules

Aim: To perform coating of granules.

Theory:

Granulation is a technique of particle enlargement by agglomeration, is one of the significant unit operations in the production of pharmaceutical dosage forms, mostly and capsules. During the granulation process, small fine or coarse particles are convened into large agglomerates called granules.

Generally, granulation commences after initial dry mixing of the necessary powder ingredients along with the active pharmaceutical ingredient so that a uniform distribution of each ingredient throughout the powder mixture is achieved.

Coating composition

Ingredients	Qty Given	Qty Taken
Hydroxy propyl methyl cellulose	4%
Propylene glycol	1.2%
Ethyl alcohol	45%
Methylene chloride	q.s. ad 100%

Procedure:

Preparation of Coating Solution: Add the polymer gradually to the ethyl alcohol and agitate the solvent with continuous stirring.
Add the some portion of methylene chloride to this suspension so that polymer gets solubilized.
Add the propylene glycol and remainder of methylene chloride to the above solution under constant stirring and the final mixture is mixed well by continuous stirring for 15-20 min.
Filter the prepared coating solution.

Granules Coating Operation:

Place 200 g of plain granules in the coating pan with three pieces of baffles installed.
The plain granules are heated to 4040°C by applying hot air.
Adjust the air pressure and the spraying speed of the spray gun to produce properly atomized coating liquid.
Turn on the coating pan and change the rotation speed to 20 rpm.
Spray the coating liquid onto the granules until a uniform film coating is formed.
Keep the distance of 25 inches of coating from the granule bed for efficient coating.
Stop spraying and keep the coating pan running for an additional few minutes to avoid sticking between the coated granules.
The granules were dried after coating by blowing air.

Observations of film coated granules

Test	Observation	Inference
Coating	Uniform/Non uniform	Passes/Fail
Dark marks	Uniform/Non uniform	Passes/Fail

Precautions While Coating:

During the coating process, the selection of the spraying rate of the coating liquid and the air blowing speed should be made with the aim not to over-wet the granules and to prevent sticking.
The temperature should not be too high or too low. If the temperature is too high. the coating film formed will not be uniform; on the other hand, if the temperature is too low, drying will be very slow and the coated granules may stick to each other.
Air bubbles should be avoided during the coating process.
The coating materials should be passed through a 150-200-mesh sieve if particle agglomeration is present (or homogenized by using a homogenizer).

Results: Plain granules are uniformly film coated and submitted.

Industrial Pharmacy I Practical

Third Year B Pharm Notes, Syllabus, Books, PDF Subjectwise/Topicwise

T Y B Pharm Sem V	T Y B Pharm Sem VI
BP501T Medicinal Chemistry II Theory	BP601T Medicinal Chemistry III Theory
BP502T Industrial Pharmacy Theory	BP602T Pharmacology III Theory
BP503T Pharmacology II Theory	BP603T Herbal Drug Technology Theory
BP504T Pharmacognosy II Theory	BP604T Biopharmaceutics and Pharmacokinetics Theory
BP505T Pharmaceutical Jurisprudence Theory	BP605T Pharmaceutical Biotechnology – Theory
BP506P Industrial Pharmacy I Practical	BP606T Quality Assurance Theory
BP507P Pharmacology II Practical	BP607P Medicinal chemistry III Practical
BP508P Pharmacognosy II Practical	BP608P Pharmacology III Practical
	BP609P Herbal Drug Technology Practical

Coating of tablets: film coating of tablets/granules