What is Sildenafil?
Sildenafil, sold under the name Viagra among others, may be a medication wont to treat male erecticle dysfunction and pulmonary arterial hypertension.
It’s unclear if it’s effective for treating sexual dysfunction in women. it’s taken orally or injection into a vein. Onset is usually within 20 minutes and lasts for about 2 hours.
Common side effects include headaches, heartburn, and flushed skin. Caution is suggested in those with disorder . Rare but serious side effects include a protracted erection which will cause damage to the penis, vision problems, and deafness .
Sildenafil shouldn’t be taken by people on nitrates like nitroglycerin (glycerin trinitrate), as this might end in a significant drop by vital sign .
Sildenafil acts by blocking phosphodiesterase 5 (PDE5), an enzyme that promotes breakdown of cGMP, which regulates blood flow within the penis. It requires arousal , however, to work. It also leads to dilation of the blood vessels within the lungs.
Pfizer originally discovered the medication in 1989 while trying to find a treatment for heart-related pain . it had been approved for medical use within the us and Europe in 1998. In 2017, it had been the 217th most ordinarily prescribed medication within the us , with quite two million prescriptions.
In 2017, it became available as a generic medication after final patents by Pfizer expired. within the uk , it’s available over the counter. As of 2018 within the us , the wholesale cost is a smaller amount than US$1 per dose.
The primary indication of sildenafil is treatment of male erecticle dysfunction (inability to sustain a satisfactory erection to finish sexual intercourse). Its use is now one among the quality treatments for male erecticle dysfunction , including for men with DM .
Antidepressant-associated sexual dysfunction
Tentative evidence suggests that sildenafil may help men who experience antidepressant-induced male erecticle dysfunction .
While sildenafil improves some markers of disease in people with pulmonary arterial hypertension, it doesn’t appear to affect the danger of death or serious side effects as of 2014.
Sildenafil and other PDE5 inhibitors are used off-label to alleviate vasospasm and treat severe ischemia and ulcers in fingers and toes for people with secondary Raynaud’s phenomenon; these drugs have moderate efficacy for reducing the frequency and duration of vasospastic episodes. As of 2016, their role more generally in Raynaud’s wasn’t clear.
High-altitude pulmonary edema
Sildenafil has been studied for high-altitude pulmonary edema, but its use is currently not recommended for that indication.