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Determination of moisture content and loss on drying: Pharm Engg Lab

Pharmaceutical Engineering Practical Lab Manual PDF Download

AIM:

To determine the moisture content and loss on drying.

REQUIREMENTS:

  • Petri dish
  • Measuring cylinder
  • Pipette
  • Tray dryer
  • Calcium carbonate
  • Spatula
  • Weighing balance

PROCEDURE:

  • Take a clean dry Petri dish and weigh it (x)
  • Weigh 10g of calcium carbonate powder and transfer to Petri dish and weight it
  • Add a sufficient amount of water with the help of a pipette to the powder until slurry forms.
  • Again weigh the Petri dish and note down weight (y)
  • Place the Petri dish in a tray dryer and weigh it every 5 min
  • Allow it to dry until it’s constant weight then down the constant dry weight (z)
  • Calculate the percentage loss on drying and moisture content for the sample.

REPORT:

The moisture content and loss on drying were determined
The percentage of moisture content is =
The loss on drying is =

Calculation:

  • Weight of empty petridish (x) =
  • Weight of empty petridish + sample + water (y) = Weight of empty petridish + sample + water (After drying at every 5 minutes) =
  • Loss of drying =

Pharm Engg Chapterwise MCQ: UNIT-I MCQ * Flow of fluids * Size reduction * Size separation UNIT-II MCQ *Heat transfer *Distillation *Evaporation UNIT-III MCQ *Drying * Mixing UNIT-IV MCQ * Filtration * Centrifugation * UNIT-V MCQ Materials of construction * Corrosion

Pharmaceutical Engineering Practical Lab Manual PDF Download

I. Determination of radiation constant of brass, iron, unpainted and painted glass.
II. Steam distillation – To calculate the efficiency of steam distillation.
III. To determine the overall heat transfer coefficient by the heat exchanger.
IV. Construction of drying curves (for calcium carbonate and starch).
V. Determination of moisture content and loss on drying.
VI. Determination of humidity of the air – i) From wet and dry bulb temperatures –use of Dew point method.
VII. Description of Construction working and application of Pharmaceutical Machinery such as rotary tablet machine, fluidized bed coater, fluid energy mill, dehumidifier.
VIII. Size analysis by sieving – To evaluate size distribution of tablet granulations – Construction of various size frequency curves including arithmetic and logarithmic probability plots.
IX. Size reduction: To verify the laws of size reduction using a ball mill and determining Kicks, Rittinger’s, Bond’s coefficients, power requirement and critical speed of Ball Mill.
X. Demonstration of colloid mill, planetary mixer, fluidized bed dryer, freeze dryer and such other major equipment.
XI. Factors affecting Rate of Filtration and Evaporation (Surface area, Concentration and Thickness/ viscosity)
XII. To study the effect of time on the Rate of Crystallization.
XIII. To calculate the uniformity Index for a given sample by using Double Cone Blender.

Second Year B Pharm Notes, Syllabus, Books, PDF Subjectwise/Topicwise

S Y B Pharm Sem IIIS Y B Pharm Sem IV
BP301T Pharmaceutical Organic Chemistry II TheoryBP401T Pharmaceutical Organic Chemistry III Theory
BP302T Physical Pharmaceutics I TheoryBP402T Medicinal Chemistry I Theory
BP303T Pharmaceutical Microbiology TheoBP403T Physical Pharmaceutics II Theory
BP304T Pharmaceutical Engineering TheoryBP404T Pharmacology I Theory
BP305P Pharmaceutical Organic Chemistry II Practical BP405T Pharmacognosy I Theory
BP306P Physical Pharmaceutics I PracticalBP406P Medicinal Chemistry I Practical
BP307P Pharmaceutical Microbiology PracticalBP407P Physical Pharmaceutics II Practical
BP308P Pharmaceutical Engineering PracticalBP408P Pharmacology I Practical
BP409P Pharmacognosy I Practical

Suggested Readings

Recommended readings:

  • Roll on deodrant base ingredients

  • Use Aartificial Intelligence for optimisation of pharmaceutical formulation

  • Bayesian approch for optimisation of pharmaceutical formulation