Cod Liver Oil Emulsion I.P. Pharmaceutics Lab Manual PDF
Aim: To Prepare, Evaluate and Submit Cod Liver Oil Emulsion I.P.
- Requirements:
- Chemicals: Cod Liver Oil, Acacia, Tragacanth, Benzaldehyde Spirit, Saccharin Sodium, Chloroform
- Apparatus: Beaker, Measuring Cylinder, Mortar and Pestle
- Theory:
Cod liver oil is fixed oil obtained from the fresh liver of the cod fish. Cod liver oil contains vitamin A & D, vital nutrients for immune system function, cellular growth, reproduction etc. Cod liver oil emulsion is given in case of the deficiency of vitamin A and D as an anti rachitic. The emulsion is prepared by the dry gum method. Acacia is the emulsifying agent and tragacanth is emulsion stabilizer. Saccharin sodium is used as the sweetening agent. Benzaldehyde spirit is used as the flavouring agent and chloroform is used as the preservative.
- Procedure:
- Accurately weigh all the ingredients.
- Take the cod liver oil in dry mortar, then add gum acacia and tragacanth powder in it.
- Add the required volume of water to produce the primary emulsion.
- Triturate the above mixture in one direction only until a primary emulsion is formed.
- Then dilute with a small portion of water and add the saccharin sodium solution, benzaldehyde spirit and chloroform with constant stirring.
- Finally, make up the volume with purified water.
- Transfer the preparation to a suitable container and label.
- Category: Source of vitamin A and D (Anti-rachitic)
● Storage: Store in a well-closed container in a cool place. Protected from light to prevent the degradation of vitamin A.
- Direction: Shake well before use.
Definitions:
- Anti-rachitic: These are the agents which are used to prevent or cure rickets.
- Emulsifying agents: Emulsifying agents are the third substance or agent which produce the film at the interface between two immiscible liquids and stabilized the system, those agents are called emulsifying agent or emulsifier or emulgent.
- Stabilizing agent/Stabilizers: A stabilizer is any substance that is used to preserve the physical and chemical properties of a material and prevent degradation. At a chemical level, these stabilizers work by inhibiting chemical reactions.
- Preservatives: The chemical substances used in various pharmaceutical dosage forms and cosmetic preparations to prevent or inhibit microbial growth.
- Sweetening agent: The agents are usually added in pharmaceutical dosage form to mask the bitter taste of the partially dissolved drugs. These agents help to improve the palatability of the formulation.
- Flavouring Agent: The agents are usually added in pharmaceutical dosage form to give flavour to the pharmaceutical formulation.
- Vehicle: Vehicles or solvents are the medium in which ingredients of a formulation are dissolved, suspended or dispersed.
