May 20, 2024

Chlorobutanol Synthesis

Shikimic Acid Pathway is a metabolic pathway that is found in plants, fungi, and some bacteria

Chlorobutanol Synthesis

BP607P Medicinal Chemistry III Practical: I Preparation of drugs Sulphanilamide * 7-Hydroxy, 4-methyl coumarin * Chlorobutanol * Triphenyl imidazole * Tolbutamide * Hexamine II Assay of drugs Isonicotinic acid hydrazide * Chloroquine * Metronidazole * Dapsone * Chlorpheniramine maleate * Benzyl penicillin III Microwave irradiation technique Synthesis of Phenytoin by Microwave * Synthesis of Aspirin by Microwave IV Drawing structures and reactions using chem draw®


To Prepare and submit chlorbutanol from acetone and calculate the Percentage Yield.


Chlorbutanol is also known as Chloroketone. It is a trichloro derivative of tertiary butyl alcohol.
It is prepared by combination with acetone and chloroform in the presence of solid potassium hydroxide Chlorobutanol is used as local anaesthetic in dental preparation and also antiseptic.


Synthesis of Chlorbutanol

Chemical Required:

Chloroform – 11 ml
Potassium hydroxide – 1 gm
Acetone – 14 ml


About 11 ml of chloroform and 1 gm of solid potassium hydroxide are taken in a round bottom flask shake until the potassium hydroxide dissolves.
To this 14 ml of acetone was added and shaken for 15 minutes.
Then set aside for half an hour and crystal of chlorbutanol was separated out.

Melting Point: 95oC – 99oC


Local anaesthetics


Chlorbutanol was Prepared and submitted and reported the following

  1. Theoretical Yield =
  2. Practical Yield =
  3. Percentage yield =

Third Year B Pharm Notes, Syllabus, Books, PDF Subjectwise/Topicwise

T Y B Pharm Sem VT Y B Pharm Sem VI
BP501T Medicinal Chemistry II TheoryBP601T Medicinal Chemistry III Theory
BP502T Industrial Pharmacy TheoryBP602T Pharmacology III Theory
BP503T Pharmacology II TheoryBP603T Herbal Drug Technology Theory
BP504T Pharmacognosy II TheoryBP604T Biopharmaceutics and Pharmacokinetics Theory
BP505T Pharmaceutical Jurisprudence TheoryBP605T Pharmaceutical Biotechnology – Theory
BP506P Industrial Pharmacy I PracticalBP606T Quality Assurance Theory
BP507P Pharmacology II PracticalBP607P Medicinal chemistry III Practical
BP508P Pharmacognosy II PracticalBP608P Pharmacology III Practical
BP609P Herbal Drug Technology Practical

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