Chemical Mediators of inflammation

Chemical mediators of inflammation are a group of substances that are released by cells in response to tissue injury, infection, or immune activation. They play a crucial role in the initiation and regulation of the inflammatory response, which is a complex biological process that involves various cells, tissues, and organs in the body.

Some of the key chemical mediators of inflammation include:

1. Histamine: Histamine is released by mast cells and basophils in response to tissue injury or allergen exposure. It causes vasodilation, increased vascular permeability, and smooth muscle contraction, leading to symptoms such as redness, swelling, and itching.
2. Prostaglandins: Prostaglandins are lipid mediators that are synthesized by various cells in the body, including macrophages and endothelial cells. They contribute to vasodilation, increased vascular permeability, and pain sensation, and are involved in the regulation of fever.
3. Leukotrienes: Leukotrienes are lipid mediators that are synthesized by leukocytes, including neutrophils and macrophages. They are potent chemotactic agents, attracting and activating other leukocytes to the site of inflammation.
4. Cytokines: Cytokines are small proteins that are secreted by various cells, including immune cells and endothelial cells. They play a critical role in the regulation of inflammation, by activating immune cells and inducing the expression of adhesion molecules on endothelial cells.
5. Chemokines: Chemokines are a subset

Second Year Pharm D Subjects

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