Novel Drug Delivery Systems NDDS Theory, Notes, PDF
Unit-I
Controlled drug delivery systems
Introduction, terminology/definitions and rationale, advantages, disadvantages, selection of drug candidates.
Approaches to design controlled release formulations based on diffusion, dissolution and ion exchange principles.
Physicochemical and biological properties of drugs relevant to controlled release formulations
Polymers
Introduction, classification, properties, advantages and application of polymers in the formulation of controlled release drug delivery systems.
Unit-II
Microencapsulation
Definition, advantages and disadvantages, microspheres /microcapsules, microparticles, methods of microencapsulation, applications
Mucosal Drug Delivery system
Introduction, Principles of bioadhesion / mucoadhesion, concepts, advantages and disadvantages, transmucosal permeability and formulation considerations of buccal delivery systems
Implantable Drug Delivery Systems
Introduction, advantages and disadvantages, the concept of implants and osmotic pump
Unit-III
Transdermal Drug Delivery Systems
Introduction, Permeation through the skin, factors affecting permeation, permeation enhancers, basic components of TDDS, formulation approaches
Gastroretentive drug delivery systems
Introduction, advantages, disadvantages, approaches for GRDDS – Floating, high-density systems, inflatable and gastroadhesive systems and their applications
Nasopulmonary drug delivery system
Introduction to Nasal and Pulmonary routes of drug delivery, Formulation of Inhalers (dry powder and metered dose), nasal sprays, nebulizers
Unit-IV
Targeted drug Delivery
Concepts and approaches advantages and disadvantages, introduction to liposomes, niosomes, nanoparticles, monoclonal antibodies and their applications
Unit-V
Ocular Drug Delivery Systems
Introduction, intraocular barriers and methods to overcome Preliminary study, ocular formulations and ocuserts
Intrauterine Drug Delivery Systems
Introduction, advantages and disadvantages, development of intrauterine devices (IUDs) and applications
Recommended Books: (Latest Editions)
- Y W. Chien, Novel Drug Delivery Systems, 2nd edition, revised and expanded, Marcel Dekker, Inc., New York, 1992.
- Robinson, J. R., Lee V. H. L, Controlled Drug Delivery Systems, Marcel Dekker, Inc., New York, 1992.
- Encyclopedia of Controlled Delivery. Edith Mathiowitz, Published by Wiley Interscience Publication, John Wiley and Sons, Inc, New York. Chichester/Weinheim
- N.K. Jain, Controlled and Novel Drug Delivery, CBS Publishers & Distributors, New Delhi, First edition 1997 (reprint in 2001).
- S.P. Vyas and R.K. Khar, Controlled Drug Delivery -concepts and advances, Vallabh Prakashan, New Delhi, First edition 2002.
Journals
- Indian Journal of Pharmaceutical Sciences (IPA)
- Indian Drugs (IDMA)
- Journal of Controlled Release (Elsevier Sciences)
- Drug Development and Industrial Pharmacy (Marcel & Decker)
- International Journal of Pharmaceutics (Elsevier Sciences)
Final Year B Pharm Notes, Syllabus, Books, PDF Subjectwise/Topicwise