Assay of Hydrogen peroxide IP Pharmaceutical Analysis I Practical
Pharmaceutical Analysis I Practical: Limit test for (1) Chloride (2) Sulphate (3) Iron (4) Arsenic Preparation and standardisation of (1) Sodium hydroxide (2) Sulphuric acid (3) Sodium thiosulfate (4) Potassium permanganate (5) Ceric ammonium sulphate Assay (1) Ammonium chloride (2) Ferrous sulphate(3) Copper sulphate (4) Calcium gluconate (5) Hydrogen peroxide (6) Sodium benzoate (7) Sodium Chloride Determination of Normality (1) Conductometric titration of strong acid against a strong base (2) Conductometric titration of strong acid and weak acid against a strong base (3) Potentiometric titration
Aim
To determine the percent content of hydrogen peroxide in a given solution.
Principle
This determination is permanganometric type of redox titration. Potassium permanganate is a strong oxidizing agent that oxidizes hydrogen peroxide to oxygen and itself gets reduced to Mn2+. Since permanganometric titrations are performed at highly acidic conditions, sulphuric acid is used in the titration. The potassium permanganate solution is always taken in the burette as the titrant., excess potassium permanganate indicates the endpoint of titration and the titrant acts as a self indicator. The endpoint is the appearance of permanent faint pink color
Standard
Hydrogen Peroxide (Mol. Wt. 34) Solution (20 vol) contains not less than 5.0
% w/v and not more than 7.0 % w/v of H2O2. Hydrogen Peroxide Solution (100 vol) contains not less than 26.0 per cent w/w and not more than 28.0 per cent w/w of H2O2.
Procedure
For 20 vol solution:
To 1.0 ml add 20 ml of 1 M sulphuric acid and titrate with 0.02 M potassium permanganate.
For 100 vol solution Dilute about 1.0 g to 100.0ml with water. To 10.0ml of the resulting solution add 20 ml of 1 M sulphuric acid and titrate with 0.02 M potassium permanganate.
Reference
Indian Pharmacopoeia 2014; Vol. II; Pg. No. 1912-1913
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