Assay of Ferrous sulphate IP Pharmaceutical Analysis I Practical
Pharmaceutical Analysis I Practical: Limit test for (1) Chloride (2) Sulphate (3) Iron (4) Arsenic Preparation and standardisation of (1) Sodium hydroxide (2) Sulphuric acid (3) Sodium thiosulfate (4) Potassium permanganate (5) Ceric ammonium sulphate Assay (1) Ammonium chloride (2) Ferrous sulphate(3) Copper sulphate (4) Calcium gluconate (5) Hydrogen peroxide (6) Sodium benzoate (7) Sodium Chloride Determination of Normality (1) Conductometric titration of strong acid against a strong base (2) Conductometric titration of strong acid and weak acid against a strong base (3) Potentiometric titration
To determine the percent purity of Ferrous sulfate in a given sample
This determination is cerimetric type of redox titration. Ceric ammonium nitrate is a strong oxidizing agent that oxidizes ferrous ions to ferric ions and undergoes reduction to convert from ceric ion to cerous ion. Ferroin sulfate is used as an indicator which is a red-coloured complex of ferrous ions with 1, 10- phenanthroline. At the equivalence point excess of ceric ions converts ferrous in ferroin to ferric which changes the colour of the solution from red to light green colour
Ferrous sulphate contains not less than 98% and not more than 105 % of FeSO4.7H2O
Dissolve 2.5g of sodium bicarbonate in a mixture of 150 ml of water and 10 ml of sulphuric acid. When effervescence ceases, add about 0.5 g of substance under examination, accurately weighed, shake gently to dissolve, and titrate with 0.1 M Ceric ammonium nitrate using 0.1 ml of ferroin solution as an indicator until the red colour disappears
Indian Pharmacopoeia 2014; Vol. II; Pg. No. 1753-1754.
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