Beta lactum antibiotics, mechanism of action, medicinal chemistry, pharmacology

What is Beta lactam antibiotics

Beta-lactam antibiotics are antibiotics that contain a beta-lactam ring in their molecular structure. This includes penicillin derivatives, cephalosporins, monobactams, carbapenems and carbacephems
Betalactam antibiotics are used in the management and treatment of bacterial infections

What are beta-lactam antibiotics examples? Give examples of beta-lactam antibiotics.

Penicillin G.
Amoxicillin.
Cephalosporin C.
Cefoxitin.
Thienamycin.
Aztreonam.
Clavulanic Acid.

Nomenclature of beta-lactam antibiotics

β-lactams fused to saturated five-membered rings:β-lactams containing thiazolidine rings are named penams.
β-lactams containing pyrrolidine rings are named carbapenams.
β-lactams fused to oxazolidine rings are named oxapenams or clavams.
β-lactams fused to unsaturated five-membered rings:β-lactams containing 2,3-dihydrothiazole rings are named penems.
β-lactams containing 2,3-dihydro-1H-pyrrole rings are named carbapenems.
β-lactams fused to unsaturated six-membered rings:β-lactams containing 3,6-dihydro-2H-1,3-thiazine rings are named cephems.
β-lactams containing 1,2,3,4-tetrahydropyridine rings are named carbacephems.
β-lactams containing 3,6-dihydro-2H-1,3-oxazine rings are named oxacephems.
β-lactams not fused to any other ring are named monobactams.

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