Pharmaceutics I MU BPH_C_403_T




Pharmaceutics I

No. Details Hours
1. Introduction-
Historical background of Profession of Pharmacy in India in brief 2
Brief overview of status of Pharmaceutical Industry in India
Pharmacopoeias-IP, BP & BPC, USP/NF, International Pharmacopoeia, Eur. Pharmacopeia
2. Overview –
Revision of dosage forms and routes of administration
Introduction to alternate systems of medicine-Ayurveda, Homeopathy, Unani & Siddha 2
Concepts of GMP & Quality Assurance in Pharma Industry
Preformulation-importance and need.
3. Packaging of Pharmaceuticals-
General concept of package and its components-primary & ancillary packs, basic packaging 2
materials- glass, plastics, metals, rubber and paper; types of containers and closures; quality
control tests; brief on adhesives and printing inks.
4. Monophasic Liquid dosage forms:Preformulation & formulation aspects
General considerations of liquid dosage form design and manufacture-selection of vehicle and
excipients; solubility and solubilisation techniques, dissociation and partitition coefficient,
polymorphism, organoleptic properties, stability with excipients. 10
Large scale Manufacturing aspects-Unit operations and equipment used:  liquid mixing,
clarification and filtration, filling operations, packaging and quality control tests.
Brief coverage of following monophasic dosage forms- Solutions, Aromatic waters, Syrups,
Elixirs, Linctuses, Nasal & Ear drops, Paints, Sprays, Lotions & Liniments.
5. Micromeritics & Powder Technology: Preformulation & formulation aspects
Basics  of  micromeritics-Fundamental  and  derived  properties  of  powders  and  their
measurement-particle shape & size, surface area, densities, flow properties, packing properties,
fluidization of powders.
Large scale manufacturing aspects- Unit operations and equipment used: Size reduction, size
separation, powder mixing, segregation of mixed powders; packaging & Q.C. of powders.
Brief coverage of following powders-Dusting powders, Oral rehydration powders, Dry syrup 10
formulations.
6. Biological products-
Sutures & ligatures– Definition, classification, cat gut manufacturing and processing, other
absorbable sutures-natural & synthetic; Nonabsorbable sutures- silk, linen, polyamides,
polyesters, polyolefins, and metallic wires; Quality control tests for sutures/ligatures
Blood products: 10
Need, problems/hazards, blood banking procedures
Whole human blood, Red cell concentrate, Platelet concentrate, Plasmapheresis, plasma, serum;
Fractionation of plasma, study of some fractions-clotting factors like fibrinogen, AHF, factor IX
complex, prothrombin, albumin preparations, γ globulin preparations. Quality control aspects of
blood products
Plasma substitutes (plasma volume expanders)
Need, desired properties, examples- hydrolyzed gelatin based products, HETA starch, Dextran
(in detail –source, preparation, official injections )
Total 36





Books-

  1. Lachman Leon, Lieberman Herbert A, Kanig Joseph L., “The Theory and Practice of Industrial Pharmacy, Varghese Publishing House, Mumbai.
  2. Remington, The Science and Practice of Pharmacy, Vol I & II, B.L. Publications Pvt. Ltd.
  3. Martin A., Physical Pharmacy, 4th Edition, Lea & Febiger, Philadelphia, London.
  4. E. Aulton, Ed, Pharmaceutics-The Science of Dosage Form Design, Churchill Livingstone Medical Divison of Longman Group, UK Ltd.
  1. Rawlings, Bentley’s Text Book of Pharmaceutics, Bailliere Tindall, London.
  2. Atmaram Pawar, “Introduction to Pharmaceutics”, Career Publications, Nashik

Pharmacopoeias- IP, BP, USP

For Pharma News and Conferences: Click here
For Online Shopping Offers : Click Here