Pharmaceutical Engineering MU BPH_C_305_T




Pharmaceutical Engineering

No. Details Hours
1 Fluid flow 3
Mention of fluid properties such as viscosity, compressibility and surface tension of fluids.
Hydrostatics influencing fluid flow.
Fluid dynamics‐ Bernoulli’s theorem, flow of fluids in pipes, laminar and turbulent flow.
2 Fluid and pressure measurements 3
Measurement of flow‐ Classification of flow meters, venturi meter,
Orifice meter, pitot tube, rotameter and current flow meters.
Pressure  measurement  ‐   Classification  of  manometers,  simple  manometer,  U  tube
manometer and modifications, Bourdon gauge.
3 Pumps: 2
Positive displacement pumps‐reciprocating pumps, rotary pumps.
Centrifugal pumps
4 Heat and Mass transfer 3
Modes of heat transfer‐ conduction, convection and radiation, Heat
exchangers‐tubular and plate.
Temperature measurement‐basic principles and devices.
Mass transfer in turbulent and laminar flow.
Concept of interfacial mass transfer
5 Conveying of solids 1
Belt conveyor, Bucket conveyor, Screw conveyor and Pneumatic conveyor.
6 Crystallization 4

 

Crystal forms and crystal habits, Mier’s theory of supersaturation, Nucleation, Crystal
growth.
Crystallizers‐ Classification, Tank crystallizers, Agitated tank crystallizers, Swenson Walker
crystallizer, Vacuum crystallizer and its modifications, Krystal or Oslo crystallizer.
Factors affecting crystallization and Caking of crystals
7 Evaporation: 6
Introduction, concept of heat transfer across the wall of evaporator, factors influencing rate
of evaporation, including scale formation
Evaporators  classification  ‐   Pan  evaporators,  Tubular  evaporators  -Horizontal  tube
evaporator, Vertical tube evaporators‐ short tube vertical evaporator, Long tube evaporators
‐Climbing film evaporator, Falling film evaporator, Forced circulation evaporator, Wiped
film evaporator , and Centrifugal rotary evaporator.
Multiple effect evaporator-principle, operation, economy, capacity efficiency and feeding
methods of evaporation.
Vapor recompression- mechanical and thermal compression principle
Evaporator  accessories‐   condensers,  vacuum  pumps,  expansion  and  bucket  traps,
entrainment separators
8 Distillation: 5
Revision of Vapour‐liquid equilibrium.
Distillation methods‐ Equilibrium distillation, Simple distillation
Fractional distillation‐ Theory of batch fractionation, Columns (only
construction and working) Bubble cap, sieve plate columns, valve plate column, packed
columns.
Concept of plate efficiency with respect to vapor equilibrium diagram and HETP (no
detailed theories and derivations).
Distillation under reduced pressure‐  Theory and applications of molecular distillation and
equipment including falling film and centrifugal molecular distillation still.
Azeotropic and Extractive distillation, Steam distillation‐ Theory and applications.
9 Refrigeration: 2
Refrigeration – equipment and concept of refrigeration load, concepts of brine systems and
absorption systems.
10 Materials of construction and Corrosion: 4
Classification into metals and non‐metals.
Ferrous and its alloys‐cast iron, mild steel and stainless steel.
Copper and its alloys.
Nickel and its alloys.
Aluminium and its alloys.
Plastics‐   Classification into thermoplastics and thermosetting plastics, properties and
applications of polyvinyl chloride, polyethylene, polyporopylene, polystyrene, polyester,
ABS,  phenolic  and  epoxy  plastics,  fluorocarbon  plastics,  chlorinated  plastics  and
polycarbonated plastics.
Corrosion:
Mechanism and types of corrosion. Factors influencing rate of corrosion. Methods of
combating corrosion.
11 Industrial Hazards and safety regulations: 3
Mechanical hazards and prevention.
Electrical hazards and prevention
Chemical hazards and prevention
Fire hazards and extinguishers
TOTAL 36




Books:

 

  1. Sambamurthy, Pharmaceutical Engineering, New age international (P) Limited Publishers, 1998.
  2. A. R. Paradkar, Introduction to Pharmaceutical Engineering, 10th Edition, Nirali Parakashan, 2007.
  3. James Swarbrick & James C. Boylon, Encyclopedia of Pharmaceutical Technology, Marcel Dekker, INC, New York, 1994.
  4. Walter I. Badger & Julius T. Bancher, Introduction to Chemical Engineering, Mc Graw Hill Inc, 1995.

 

  1. E. Aulton, Ed, Pharmaceutics‐The Science of Dosage Form Design, Churchill Livingstone Medical Division Of Longman Group UK Ltd, 2002.

 

  1. J. Carter, Cooper and Gunn’s Tutorial Pharmacy, 6th Edition, CBS Publishers & Distributors, New Delhi, 2005.

 

  1. Robert H. Perry, Don W. Green, Perry’s Chemical Engineers Handbook,7th Edition, Don W. Green, James O. Maloney, McGraw Hill,1997.

 

  1. K. Jani, Pharmaceutical Engineering, Vallabh Prakashan.
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