Organic Chemistry MU BPH_C_401_T




Organic Chemistry

No. Details Hours References
1.0 Preparation of following functional groups: (Only 6 Organic Chemistry, R. T. Morrison,
reactions to be discussed without mechanisms) R. N. Boyd, S. K. Bhattacharjee,
Pearson Education, 7th Ed.
1.1 Alcohols by Grignards reagent, phenols by hydrolysis of
diazonium salts
1.2 Aldehydes & ketones by oxidation of primary &
secondary alcohols, Oxidation of methyl benzenes
1.3 Amines by reduction of nitro compounds
1.4 Carboxylic acids by oxidation of alcohols and hydrolysis
of nitriles
2.0 Nucleophilic addition to C=O group 6 1. Organic Chemistry, Jonathan
2.1 Nucleophilic addition to aldehydes, ketones (e.g. attack Clayden, Nick Greeves, and Stuart
of cyanide, hydride, organolithium, Grignard reagents, Warren, Oxford University Press,
water and alcohols to form hemiacetals in acidic/basic 2nd Ed., Chapter 6.
conditions) 2. Organic Chemistry, R. T.
Morrison, R. N. Boyd, S. K.
2.2 Cannizzaro and crossed – Cannizzaro reaction
Bhattacharjee, Pearson Education,
7th Ed., Chapter 12.
3.0 Nucleophilic substitution to C=0 group 10 1. Organic Chemistry, Jonathan
3.1 Concept of leaving group based on stability and pKa with Clayden, Nick Greeves, and Stuart
reference to carboxylic acid derivatives Warren, Oxford University Press,
2nd Ed., Chapter 10.
3.2 Discussion of tetrahedral intermediate
2. Organic Chemistry, R. T.
3.3 Examples to be discussed: Conversion of acid chloride to
esters and amides, transesterification reaction. Morrison, R. N. Boyd, S. K.
Bhattacharjee, Pearson Education,
3.4 Comparison of reactivity of various carboxylic acid
derivatives, Interconversion of carboxylic acid 7th Ed., Chapter 14
derivatives
3.5 Acid and base catalyzed hydrolysis of esters, amides.
3.6 Strategies of converting ketones to esters
3.7 Nucleophilic substitution at C=O with loss of carbonyl 1. Organic Chemistry, Jonathan
oxygen. (Examples to be discussed: Conversion of Clayden, Nick Greeves, and Stuart
aldehydes and ketones to imine, oxime, hydrazine, Warren, Oxford University Press,
semihydrazone and semi carbazide.) 2nd Ed., Chapter 11.
2. Organic Chemistry, R. T.

 

Morrison, R. N. Boyd, S. K.
Bhattacharjee, Pearson Education,
7th Ed., Chapter 12
3.8 Wittig reaction
4.0 Electrophilic addition to alkene 8 1. Organic Chemistry, Jonathan
4.1 Addition of bromine*, water, HBr (in presence and Clayden, Nick Greeves, and Stuart
absence of peroxide) to alkenes, dimerization, Warren, Oxford University Press,
oxymercuration-demercuration*, hydroboration- 2nd Ed., Chapter 19.
oxidation*, oxidation of alkenes to epoxide*, periodate 2. Organic Chemistry, R. T.
cleavage and ozonolysis*, reaction with N-bromo Morrison, R. N. Boyd, S. K.
succinimide. Bhattacharjee, Pearson Education,
(*Stereochemical aspects to be covered) 7th Ed., Chapter 6.
5.0 Enols and Enolates 6 1. Organic Chemistry, Jonathan
Clayden, Nick Greeves, and Stuart
Warren, Oxford University Press,
2nd Ed., Chapter 20
5.1 Formation and stability of enols (Pgs. 449-458)
5.2 Aldol condensation reaction, crossed Aldol and mixed 2. Organic Chemistry, R. T.
aldol reaction, Claisen and Crossed Claisen, Mannich Morrison, R. N. Boyd, S. K.
reaction, Dickmann reaction. Bhattacharjee, Pearson Education,
7th Ed.
5.3 Conjugate addition : 1,2 and 1,4 Michael addition Organic Chemistry, Jonathan
reaction Clayden, Nick Greeves, and Stuart
Warren, Oxford University Press,
2nd Ed., Pg. 504.
6.0 Electrophilic aromatic substitution 8 1. Organic Chemistry, Jonathan
6.1 Nitration, sulphonation, halogenation, Friedel-Crafts Clayden, Nick Greeves, and Stuart
alkylation and Friedel Crafts acylation. Warren, Oxford University Press,
2nd Ed., Chapter 21.
6.2 Kolbe reaction, Reimer-Tiemann reaction
2. Organic Chemistry, R. T.
6.3 Orientation and reactivity of mono and di-substituted
benzene towards electrophilic aromatic substitution Morrison, R. N. Boyd, S. K.
reaction. Bhattacharjee, 7th Ed., Pearson
Education.
7.0 Nucleophilic aromatic substitution 4 1. Organic Chemistry, R. T.
7.1 Mechanistic approach of nucleophilic aromatic Morrison, R. N. Boyd, S. K.
substitution (Bimolecular displacement and benzyne Bhattacharjee, Pearson Education,
formation) 7th Ed. Ch. 9
TOTAL 48
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