General Chemistry MU BPH_C_101_T

General Chemistry




No. Details Hours
1 Review of basic bonding concepts 10
1.1 Quantum numbers, atomic orbitals, electron configuration, electronic diagrams, polar 4
covalent bonds, electronegativity group, electronegativities, electrostatic potential
surfaces, inductive effects, bond dipoles, molecular dipoles.
1.2 Lewis structures, formal charge. 3
1.3 VSEPR, hybridization involving s, p and d orbitals, hybridization effects 3
2 Kinetics and reaction mechanism 7
2.1 Energy surfaces, reaction coordinate diagrams, activated complex/transition state rate 2
and rate constants, reaction order and rate laws
2.2 Kinetic isotope effects 2
2.3 Hammond Postulate, reactivity vs selectivity, Curtin-Hammett Principle, microscopic 3
reversibility, kinetic vs thermodynamic control
3 Catalysis: 7
3.1 General principles of catalysis, Forms of catalysis – electrophilic catalysis, acid- base 4
catalysis, nucleophilic catalysis, covalent catalysis, phase transfer catalysis.
3.2 Bronsted Acid-base catalysis, correlation of reaction rates with acidity functions. 3
4 Gastrointestinal Agents 4
4.1 Acidifying agents 1
4.2 Antacids:Sodium bicarbonate, aluminum hydroxide, calcium carbonate, tribasic 1
calcium phosphate, magnesium hydroxide, magnesium trisilicate and combination
antacid preparations.
4.3 Protectives and Adsorbents:Introduction; bismuth subnitrate, bismuth subcarbonate, 1
kaolin, attapulgite and activated charcoal
4.4 Cathartics 1
5 Topical Agents 4
5.1 Protective Topical Agents: Definition; talc, insoluble zinc compounds (zinc oxide, 1
calamine, zinc stearate), titanium dioxide.
5.2 Antimicrobials and Astringents: Antimicrobial terminology, mechanism of action 1
Antimicrobial Astringent Products:
Oxidative antimicrobial agents; (hydrogen peroxide, zinc peroxide, sodium carbonate,
potassium permanganate, sodium hypochlorite, iodine preparation and compounds)
5.3 Protein Precipitant Antimicrobial Agents: 1
Silver nitrate, mild silver protein and related products, ammoniated mercury, mercuric
chloride, sulphur and sulphur compounds, sublimed sulphur and precipitated sulphur,
boric acid and sodium borate, antimony potassium tartrate.
5.4 Astringents: Official compounds of aluminium and zinc 1
6 Complexing and chelating agents used in therapy, poisons and antidotes 2
7 Miscellaneous inorganic pharmaceutical agents: 2
7.1 Sclerosing agents, expectorants, emetics. 1
7.2 Antioxidants: Theory and principle, selection of antioxidants, official antioxidants 1
(hypophosphorous acid, sodium bisulphite, sodium thiosulphate, sodium nitrite and
nitrogen).
8 Inorganic Radio Pharmaceuticals: 4
Properties of α,β and γ radiation, biological effect of radiation, half-life, clinical
application of radiopharmaceuticals (Chromium-51, Iodine-125 and 131, Technetium-
99, Iron-59, Cobalt-57 and 60 and Gold-198)
9 Major Intra & Extracellular Electrolytes 5
9.1 Major physiological ions (Role and condition related to change in concentration of 2
following ions: chloride, phosphate, bicarbonate, sodium, potassium, calcium,
magnesium)
9.2 Electrolytes used in replacement therapy: Sodium replacement (sodium chloride), 1
potassium replacement (potassium chloride), calcium replacement (calcium chloride,
calcium gluconate)
9.3 Physiological acid base balance: 2
Acids and Bases: Buffers (Pharmaceutical and Physiological)
Electrolytes used in acid base therapy (sodium acetate, sodium bicarbonate, sodium
biphosphate, sodium citrate, sodium lactate, ammonium chloride). Electrolyte
combination therapy.
10 Essential and Trace Elements: 3
Iron and haematinics
Copper, zinc, molybdenum, selenium and sulphur. Official iodine products
(iodine,potassium iodide, sodium iodide).
TOTAL 48

Note: Only Uses of pharmaceutical agents mentioned to be covered. Monographs not to be discussed.




Books:

Latest Edition of all books to be referred.

  • Eric V Ansyln and Dennis A Dougherty, Modern Physical Organic Chemistry, John Wiley.
  • Inorganic medicinal and pharmaceutical chemistry, J. H. Block, E. B. Roche, T. O. Soine, and C. O. Wilson. Lea &Febiger, Philadelphia, PA.
  • Modern Inorganic Pharmaceutical Chemistry, Clarence A. Discher. Wiley, New York.
  • Remington: the science and practice of pharmacy, Beringer, P. Lippincott Williams & Wilkins.
  • Inorganic Pharmaceutical Chemistry, Bothara, K. G., Nirali Prakashan.
  • Inorganic Pharmaceutical Chemistry, A. S. Dhake, H. P. Tipnis, Career Publication.
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