|1||Carbohydrate metabolism discussed with respect to the structures of||20|
|intermediates, enzymes and cofactors, energy yield/requirements and regulation.|
|Examples of drugs modulating carbohydrate metabolism.|
|1.1||Glycolysis (Embden Meyerhoff Pathway), TCA cycle (Kreb’s Cycle, Citric acid||08|
|Cycle) and glyoxalate shunt. Entry of sugars other than glucose into glycolytic|
|pathway. Discussion of shuttle systems to transfer NADH to the mitochondria.|
|1.2||Electron Transport Chain discussed with respect to the components of the ETC,||04|
|explanation of oxidative phosphorylation vs substrate level phosphorylation.|
|Discussion of proton motive force and generation of ATP using proton gradients.|
|Discussion of uncouplers of oxidative phosphorylation.|
|1.3||Discussion of pentose phosphate pathway, glycogenesis, glycogenolysis,||08|
|gluconeogenesis and other systems involved in carbohydrate metabolism|
|2||Lipid metabolism discussed with respect to the structures of intermediates,||18|
|enzymes and cofactors involved, energy yield/requirements and regulation.|
|2.1||Beta oxidation pathway for catabolism of saturated and unsaturated even number||08|
|fatty acids, catabolism of odd number carbon containing fatty acids, formation of|
|2.2||Acetate mevalonate pathway to cholesterol biosynthesis,||04|
|2.3||Biosynthesis of fatty acids, prostaglandins, leukotrienes and phospholipids.||04|
|2.4||Examples of drugs modulating lipid/cholesterol metabolism.||02|
|3||Nucleic Acid Metabolism discussed with respect to the structures of||10|
|intermediates, enzymes and cofactors, energy yield/requirements and regulation|
|3.1||Discussion of biosynthesis of purines.||04|
|3.2||Discussion of biosynthesis of pyrimidines.||02|
|3.3||Salvage pathways for nucleic acid metabolism. Examples of drugs modulating||04|
- Lehninger, Principles of Biochemistry, Replika Press.
- Stryer L, Biochemistry, W. H. Freeman & Co.
- Harper’s Biochemistry, Appleton and Lange, USA.
- Conn E, Stumpf PK, Brueing G and Doi Roy H, Outlines of Biochemistry, Wiley Liss, USA.
- Wilson and Gisvolds Textbook of Organic Medicinal and Pharmaceutical Chemistry, Lippincott Willliams and Wilkins, USA
- Foye’s Principles of Medicinal Chemistry, Lippincott Williams and Wilkins, USA.
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