Biochemistry I MU BPH_C_104_T

Biochemistry I




No. Details Hours
1. Introduction to Carbohydrates: 22
Introduction to common monosaccharides ranging from trioses to hexoses
Introduction to common disaccharides sucrose, cellobiose, maltose, lactose
Introduction to common polysaccharides starch and glycogen
Introduction to Proteins:
Introduction to amino acids, their classification, three letter and one letter codes
Introduction to hierarchy of protein structures
Introduction to Lipids:
Introduction to common saturated and unsaturated fatty acids
Introduction to triacyl glycerol, phospholipids, sphingolipids
Introduction to Nucleic acids:
Introduction to nitrogen bases, nucleosides and nucleotides
Introduction to the structure of DNA (helices), melting and annealing of DNA,
melting temperature and introduction to higher order packaging of DNA
Introduction to the concept of glycoproteins, proteoglycans, lipopolysaccharides,
glycolipids, lipoproteins, proteolipids, nucleoproteins, with examples.
2. Vitamins 15
Vitamins as co-enzymes and their significance. Biochemical roles of all the
vitamins with details of the mechanisms of their functions. (riboflavin, thiamine,
pyridoxal, nicotinamide, biotin, folic acid, ascorbic acid, pantothenic acid,
cyanocobolamine, inositol, vitamins A, D, E, K)
3. Biochemical Energetics 8
Introduction to the concept of free energy, standard free energy, transformed free
energy. Thermodynamically favorable or unfavorable reactions. Spontaneous
versus thermodynamically favorable reactions. Oxidations as a source of energy
in biological systems. ATP, NADH and FADH2 as energy carriers. Introduction
to the concepts of anabolism and catabolism. Convergence of metabolic
pathways and divergence of anabolic pathways
4. Digestion 3
Digestion of food and absorption of food (carbohydrates, lipids and
carbohydrates). Fate of absorbed nutrients and the relationship with regard to
immediate use, storage, release and interconversion. Role of liver, muscle,
adipose tissue, brain and special features of rbcs.
TOTAL 48





Books:

  1. Lehninger, Principles of Biochemistry, Replika Press.
  2. Stryer L, Biochemistry, W. H. Freeman & Co.
  3. Harper’s Biochemistry, Appleton and Lange, USA.
  4. Conn E, Stumpf PK, Brueing G and Doi Roy H, Outlines of Biochemistry, Wiley Liss, USA.
  5. Wilson and Gisvold’s Textbook of Organic Medicinal and Pharmaceutical Chemistry, Lippincott Willliams and Wilkins, USA
  6. Foye’s Principles of Medicinal Chemistry, Lippincott Williams and Wilkins, USA.
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